Currently, ADAP waiting lists are growing at a rate of 550 people per month. As of 2011 January, more than 5,300 people are on ADAP waiting around lists, with an additional 2,500 at risk of being dropped from the program altogether. This crisis is definitely quickly worsening as many larger ADAP programs are being forced to avoid providing treatment to fresh patients. For example, Florida, which has the third highest HIV people in the country, in June 2010 that today provides 2 instituted a waiting list,816 people onto it. California has proposed cuts designed to force many sufferers off this program. In 2011, ADAPs shall have to serve an additional 25,000 individuals who cannot afford their treatment.In conclusion, we describe the integration of social-network analysis with high-resolution bacterial genome sequencing to enhance the investigation of a tuberculosis outbreak. Our data present that epidemiologic inferences are significantly improved by interpretation in the context of whole-genome sequencing and that a single M. Tuberculosis genotype contains more than enough genetic diversity to refine epidemiologic linkages on the basis of genetic clade or lineage membership. Although whole-genome sequencing may not be feasible as a routine tool for outbreak investigation currently, data generated by this and additional sequencing projects will identify probably the most informative panel of markers of genomic variability in M. Tuberculosis, facilitating the development of higher-resolution genotyping strategies.