Ebbeling, Ph.D., from Children’s Hospital, Boston, and colleagues conducted two studies to judge the effects of fast food on energy intake in over weight versus lean adolescents. Fifty-four adolescents were enrolled in the studies aged 13 to 17 years who reported eating fast food one or more times per week. Fifty-one of the 54 participants enrolled in research 1 also completed research 2. In this investigation, the experts grouped adolescents who were overweight and at risk of obese into one group and adolescents with a BMI [body mass index = excess weight in kilograms divided by the square of height in meters] not really exceeding the 85th %iles because of their ages were considered lean. In study one, participants were fed extra large fast food meals in a food court and instructed to consume as much or as little as desired during the one-hour meal.The researchers then used microarray evaluation and pre-clinical pet assays to recognize two predominant glioblastoma subtypes, mesenchymal and proneural. Key technical results include: Genes involved with glycolysis and gluconeogenesis, aLDH1A3 particularly, were considerably up-regulated in mesenchymal glioma stem cells in comparison to proneural stem cells; Mesenchymal glioma stem cells present higher radiation resistance and high expression of DNA-repair genes significantly; Radiation induces transformation of proneural glioma stem cells into mesenchymal-like glioma stem cells that are highly resistant to radiation treatment; inhibiting the ALDH1 pathway reverses this resistance.