Adolescents overeat fast food.

Ebbeling, Ph.D., from Children’s Hospital, Boston, and colleagues conducted two studies to judge the effects of fast food on energy intake in over weight versus lean adolescents. Fifty-four adolescents were enrolled in the studies aged 13 to 17 years who reported eating fast food one or more times per week. Fifty-one of the 54 participants enrolled in research 1 also completed research 2. In this investigation, the experts grouped adolescents who were overweight and at risk of obese into one group and adolescents with a BMI [body mass index = excess weight in kilograms divided by the square of height in meters] not really exceeding the 85th %iles because of their ages were considered lean. In study one, participants were fed extra large fast food meals in a food court and instructed to consume as much or as little as desired during the one-hour meal.The researchers then used microarray evaluation and pre-clinical pet assays to recognize two predominant glioblastoma subtypes, mesenchymal and proneural. Key technical results include: Genes involved with glycolysis and gluconeogenesis, aLDH1A3 particularly, were considerably up-regulated in mesenchymal glioma stem cells in comparison to proneural stem cells; Mesenchymal glioma stem cells present higher radiation resistance and high expression of DNA-repair genes significantly; Radiation induces transformation of proneural glioma stem cells into mesenchymal-like glioma stem cells that are highly resistant to radiation treatment; inhibiting the ALDH1 pathway reverses this resistance.