These results had been validated for all six genes tested . Six of the genes have already been implicated in DNA replication17 or regulation of mitosis . These results are consistent with those inside our functional studies of single hematopoietic stem progenitor and cells cells, which revealed improved proliferation when JAK2 V617F was acquired by TET2-nonmutated however, not TET2-mutated cells . Together these data show that acquisition of a prior TET2 mutation dramatically altered the transcriptional implications of JAK2 V617F in a cell-intrinsic way. In particular, it prevented JAK2 V617F from up-regulating genes connected with proliferation. Impact of Mutation Order on Clinical Presentation, Risk of Thrombosis, and Sensitivity to JAK Inhibition Inside our initial patient cohort, the ratio of patients with polycythemia vera to those with essential thrombocythemia appeared to be greater among JAK2-first patients than among TET2-first patients .Because contaminant amounts in water can vary from consuming fountain to drinking fountain, and different children drink different amounts of water, epidemiologists often have trouble calculating the potential threats to children’s health. But kids have suffered health issues related to school water: – In 2001, 28 children at a Worthington, Minn., elementary school experienced serious tummy nausea and aches after drinking water tainted with lead and copper, the result of a badly installed treatment system.