Nickerson, Ph.D., Jay Shendure, M.D., Ph.D., Annapurna Poduri, M.D., M.P.H., Timothy W. Yu, M.D., Ph.D., and Christopher A. Walsh, M.D., Ph.D.: Somatic Mutations in Cerebral Cortical Malformations Somatic mutation, a postzygotic event, leads to several populations of cells with distinct genotypes in an organism, despite development from a single fertilized egg. A notch reduced the hierarchy of severity are the somatic mutations within persons with tuberous sclerosis, the double-cortex syndrome, periventricular nodular heterotopia, and bilateral megalencephalic disorders; these persons typically have milder presentations of disease than perform those that carry the mutation within their germline.1,8,9 The broader relevance of somatic mutations to other neurologic conditions, such as autism and epilepsy in persons without structural brain malformations, is not known.The trial has been sponsored by Keryx Biopharmaceuticals, Inc., , , Aeterna Zentaris’ licensee for perifosine in THE UNITED STATES. Aeterna Zentaris has also out-licensed rights for perifosine to Handok for South Korea while retaining rights for the rest of the world. The Scientific Information from the EMA indicates that the ongoing study, in conjunction with safety data generated from various other clinical research with perifosine, is considered sufficient to supply all data essential to support a marketing authorization of perifosine in advanced colorectal cancers. Therefore, the Company will not intend to initiate any extra study with perifosine because of this indication. Related StoriesNew antenna-like device makes breast cancer medical procedures easier for surgeonsMD Anderson study reveals why chemotherapy medicines not effective for most pancreatic tumor patientsFDA grants accelerated acceptance for Tagrisso to treat patients with advanced NSCLCThe multicenter X-PECT + Perifosine Evaluation in Colorectal cancer Treatment) Phase 3 study involving approximately 430 sufferers, is a double-blind, placebo-controlled research comparing the combination of perifosine and capecitabine ) with single-agent capecitabine ).