The same advice applies to men, since a big waistline raises their risk of diabetes and cardiovascular disease also, according to Apovian. The KLF14 variant appears to influence body fat distribution in women only. But, Small said, other genes have been associated with fat diabetes and shops risk in men. More broadly, Apovian said, this study helps illustrate the need for fat cells – – their activity and structure – – to human health. ‘Fat cells don’t just sit there, storing fat,’ she said.. New Clues to How Gene Impacts Women’s PHYSIQUE, Diabetes Risk: – SATURDAY, Oct.Statistical Analysis The study plan was in line with the hypothesis that apixaban will be noninferior to enoxaparin with regards to the primary efficacy outcome, by using a prespecified noninferiority margin where the upper limit of the 95 percent confidence interval for relative risk didn’t exceed 1.25 and the upper limit of the 95 percent confidence interval for the difference in risk didn’t exceed 5.6 %age points. Both criteria had to be met to determine noninferiority.